Study: Long-term testosterone therapy improves urinary, sexual function and quality of life

Image result for Study: Long-term testosterone therapy improves urinary, sexual function and quality of life
Adapted Media Release

A new study shows a
significant improvement in both sexual and urinary function as well as quality
of life for hypogonadal men who undergo long-term testosterone replacement
These findings appear in the
Journal of Urology.
Testosterone is a steroid
hormone involved in the regulation of sexual function, urinary health and
metabolism as well as a number of other critical functions. For most men,
testosterone concentration declines slowly with age and may not cause immediate
major symptoms. However, some men may experience a host of signs and sumptoms
constituting a clinical condition called Testosterone Deficiency (TD), or male
hypogonadism, which is attributed to insufficient levels of testosterone. As a
result, they experience symptoms as varied as erectile dysfunction, low energy,
fatique, depressed mood and an increased risk of diabetes.
Researchers from the Boston
University School of Medicine (BUSM) and Public Health (BUSPH) collaborated
with a group of urologists in Germany to investigate the effects of long-term
testosterone replacement therapy on urinary health and sexual function as well
as quality of life in men with diagnosed, symptomatic testosterone deficiency.
More than 650 men in their 50s and 60s enrolled in the study, some with
unexplained testosterone deficiency and others with known genetic and
auto-immune causes for their hypogonadism.
“It is thought that
testosterone treatment in men may increase prostate size and worsen lower urinary
tract symptoms,” said Abdulmaged Traish, PhD, professor of urology at
However, he and Gheorghe
Doros, PhD, professor of biostatistics at BUSPH, discovered that despite
increased prostate size in the group that received testosterone therapy, there
were fewer urinary symptoms such as frequent urination, incomplete bladder
emptying, weak urinary stream and waking up at night to urinate.
In addition to these
subjective improvements, the researchers conducted objective testing that
showed that those men treated with testosterone emptied their bladders more
fully. Finally, testosterone treatment also increased the scores patients
received on assessments of their erectile/sexual health and general quality of
The findings of this study are
of great significance to men suffering with symptomatic testosterone
deficiency. Traish emphasized the value of this treatment option, stating that,
“[Testosterone therapy] is well-tolerated with progressive and sustained
improvement in urinary and sexual function and overall improvement in quality
of life.”

Kayode Ojo
Kayode Emmanuel Ojo is the Co-Founder and Managing Director at SHEFFA Limited. He is presently studying Computer Science at the National Open University, Victoria Island, Lagos.