What is Ultravate?
Ultravate is a brand-name
prescription medication used to treat certain skin conditions. The medication
is available in three different forms:
prescription medication used to treat certain skin conditions. The medication
is available in three different forms:
- Ultravate lotion is used to
treat plaque psoriasis in adults. With this condition, itchy, red, patches form
on your skin. Plaque psoriasis is one of many types of psoriasis. - Ultravate cream and ointment
are used to treat skin swelling and itching from skin conditions that can be
treated with a drug called a corticosteroid. (Ultravate itself is a
corticosteroid.) Some of the skin conditions that the cream and ointment may be
used for include eczema, poison ivy, and hives. Ultravate cream and ointment
are approved for use in adults as well as children ages 12 years and older.
Ultravate contains the drug
halobetasol, which belongs to a class of drugs called corticosteroids. (A class
of drugs is a group of medications that work in a similar way.) Ultravate is
considered to be a potent (strong) corticosteroid.
halobetasol, which belongs to a class of drugs called corticosteroids. (A class
of drugs is a group of medications that work in a similar way.) Ultravate is
considered to be a potent (strong) corticosteroid.
Ultravate lotion comes in a
bottle. Ultravate cream and ointment both come in a tube. You’ll apply
Ultravate to your skin once or twice a day for up to 2 weeks, or as your doctor
or pharmacist recommends.
bottle. Ultravate cream and ointment both come in a tube. You’ll apply
Ultravate to your skin once or twice a day for up to 2 weeks, or as your doctor
or pharmacist recommends.
Because of the risk of side
effects, you shouldn’t use Ultravate for longer than 2 weeks. And you shouldn’t
use more than 50 g of Ultravate a week (50 mL a week of the lotion form). For
more about side effects, see the “Ultravate side effects” section below.
effects, you shouldn’t use Ultravate for longer than 2 weeks. And you shouldn’t
use more than 50 g of Ultravate a week (50 mL a week of the lotion form). For
more about side effects, see the “Ultravate side effects” section below.
Effectiveness
In clinical studies, people
with moderate to severe plaque psoriasis were given Ultravate lotion or a placebo
(treatment with no active drug) for up to 2 weeks. After 2 weeks, 44.5% of
people who used Ultravate lotion were cleared or almost cleared of their plaque
psoriasis. This was compared with 6.3% to 7.1% of people who used a placebo.
with moderate to severe plaque psoriasis were given Ultravate lotion or a placebo
(treatment with no active drug) for up to 2 weeks. After 2 weeks, 44.5% of
people who used Ultravate lotion were cleared or almost cleared of their plaque
psoriasis. This was compared with 6.3% to 7.1% of people who used a placebo.
People who used the Ultravate
lotion saw less scaling, redness, and plaque elevation than people who used a
placebo. (Plaque elevation is skin thickening caused by the buildup of dead
skins cells.) The study results showed:
lotion saw less scaling, redness, and plaque elevation than people who used a
placebo. (Plaque elevation is skin thickening caused by the buildup of dead
skins cells.) The study results showed:
- Less scaling in 55.5% to 59.1%
of people who used Ultravate compared with 10.8% to 9.8% of people who used a
placebo - Less redness in 36.4% to 43.6%
of people who used Ultravate compared with 7.2% to 10.7% of people who used a
placebo - Less plaque elevation in 43.6%
to 45.5% of people who used Ultravate compared with 8.0% to 8.1% of people who
used a placebo
For more information about the
effectiveness of Ultravate in helping treat certain skin conditions, see the
“Ultravate uses” section below.
effectiveness of Ultravate in helping treat certain skin conditions, see the
“Ultravate uses” section below.
Ultravate generic
Ultravate contains the active
drug ingredient halobetasol. (An active drug is an ingredient in the medication
that affects how the medication works.)
drug ingredient halobetasol. (An active drug is an ingredient in the medication
that affects how the medication works.)
Ultravate is available as a
brand-name and generic medication. A generic drug is an exact copy of a
brand-name medication. Generics tend to cost less than brand-name drugs.
brand-name and generic medication. A generic drug is an exact copy of a
brand-name medication. Generics tend to cost less than brand-name drugs.
The generic form of Ultravate
is called halobetasol propionate 0.05%. You’ll need a prescription for it.
is called halobetasol propionate 0.05%. You’ll need a prescription for it.
Ultravate uses
The Food and Drug
Administration (FDA) approves prescription drugs such as Ultravate to treat
certain conditions. Ultravate may also be used off-label for other conditions.
Off-label use is when a drug that’s approved to treat one condition is used to
treat a different condition.
Administration (FDA) approves prescription drugs such as Ultravate to treat
certain conditions. Ultravate may also be used off-label for other conditions.
Off-label use is when a drug that’s approved to treat one condition is used to
treat a different condition.
Ultravate for psoriasis
Ultravate lotion is
FDA-approved to treat plaque psoriasis in adults.
FDA-approved to treat plaque psoriasis in adults.
Plaque psoriasis occurs when
your immune system is overactive, and your body makes skin cells too rapidly.
(Your immune system is your body’s defense against infection.) This causes
excess skin cells to build up on your skin’s surface. The buildup typically
appears as raised, red patches that may be covered with silver or white scales.
These patches are known as “plaques.”
your immune system is overactive, and your body makes skin cells too rapidly.
(Your immune system is your body’s defense against infection.) This causes
excess skin cells to build up on your skin’s surface. The buildup typically
appears as raised, red patches that may be covered with silver or white scales.
These patches are known as “plaques.”
Plaques most commonly appear
on your scalp, elbows, knees, and lower back, although they can show up
anywhere on your body.
on your scalp, elbows, knees, and lower back, although they can show up
anywhere on your body.
Effectiveness of Ultravate
lotion
lotion
In clinical studies, people
with moderate to severe plaque psoriasis were given Ultravate lotion or a
placebo (treatment with no active drug) for up to 2 weeks. After 2 weeks, 44.5%
of people who used Ultravate lotion were cleared or almost cleared of their
plaque psoriasis. This was compared with 6.3% to 7.1% of people who used a
placebo.
with moderate to severe plaque psoriasis were given Ultravate lotion or a
placebo (treatment with no active drug) for up to 2 weeks. After 2 weeks, 44.5%
of people who used Ultravate lotion were cleared or almost cleared of their
plaque psoriasis. This was compared with 6.3% to 7.1% of people who used a
placebo.
People who used the Ultravate
lotion saw less scaling, redness, and plaque elevation than people who used a
placebo. (Plaque elevation is skin thickening caused by the buildup of dead
skins cells.) The study results showed:
lotion saw less scaling, redness, and plaque elevation than people who used a
placebo. (Plaque elevation is skin thickening caused by the buildup of dead
skins cells.) The study results showed:
- Less scaling in 55.5% to 59.1%
of people who used Ultravate compared with 10.8% to 9.8% of people who used a
placebo - Less redness in 36.4% to 43.6%
of people who used Ultravate compared with 7.2% to 10.7% of people who used a
placebo - Less plaque elevation in 43.6%
to 45.5% of people who used Ultravate compared with 8.0% to 8.1% of people who
used a placebo
Ultravate for skin conditions
that can be treated with a corticosteroid
that can be treated with a corticosteroid
Ultravate cream and ointment
are FDA-approved to treat swelling and itching from skin conditions that can be
treated with a drug called a corticosteroid. (Ultravate itself is a
corticosteroid.) Some of these skin conditions include eczema, poison ivy, and
urticaria (hives).
are FDA-approved to treat swelling and itching from skin conditions that can be
treated with a drug called a corticosteroid. (Ultravate itself is a
corticosteroid.) Some of these skin conditions include eczema, poison ivy, and
urticaria (hives).
Ultravate cream and ointment
are approved for adults as well as children ages 12 years and older.
are approved for adults as well as children ages 12 years and older.
Eczema
Eczema is a condition that
makes your skin itchy and red, although symptoms can vary from person to
person. The most common symptoms include:
makes your skin itchy and red, although symptoms can vary from person to
person. The most common symptoms include:
- dry skin
- itching
- red patches
- small bumps that may leak
fluid - scaly or cracked skin
Eczema occurs when your skin
can’t protect itself and retain moisture. The condition is usually genetic.
Risk factors for eczema include having asthma, allergies, or a family member
who has had the condition.
can’t protect itself and retain moisture. The condition is usually genetic.
Risk factors for eczema include having asthma, allergies, or a family member
who has had the condition.
In an older clinical study,
Ultravate ointment or a placebo ointment (treatment with no active drug) was
given to people with chronic eczema for 2 weeks. By the end of the 2 weeks, 83%
of people who used Ultravate ointment were cleared or almost cleared of their
eczema plaques, compared with 28% of people who used a placebo ointment.
Ultravate ointment or a placebo ointment (treatment with no active drug) was
given to people with chronic eczema for 2 weeks. By the end of the 2 weeks, 83%
of people who used Ultravate ointment were cleared or almost cleared of their
eczema plaques, compared with 28% of people who used a placebo ointment.
Poison ivy
Poison ivy rash results from
your skin coming in contact with a substance called urushiol. This is a sap
that’s found on the stems, leaves, and roots of the poison ivy plant. Urushiol
is also found on plants called poison oak and poison sumac. Symptoms of poison
ivy rash include skin that’s itchy, red, or swollen, and blisters that may
leak.
your skin coming in contact with a substance called urushiol. This is a sap
that’s found on the stems, leaves, and roots of the poison ivy plant. Urushiol
is also found on plants called poison oak and poison sumac. Symptoms of poison
ivy rash include skin that’s itchy, red, or swollen, and blisters that may
leak.
Hives
Hives, which are also called
urticaria, are a type of rash that causes your skin to be itchy, red, and have
spots of swelling. These spots (welts) can be large or small.
urticaria, are a type of rash that causes your skin to be itchy, red, and have
spots of swelling. These spots (welts) can be large or small.
Hives result from a release of
a chemical called histamine into your bloodstream. Your immune system (your
body’s defense against infection) responds to histamine by causing redness and
itching.
a chemical called histamine into your bloodstream. Your immune system (your
body’s defense against infection) responds to histamine by causing redness and
itching.
Hives can be triggered by
infections, changes in temperature, stress, sunlight, or certain foods.
infections, changes in temperature, stress, sunlight, or certain foods.
Ultravate for other conditions
In addition to the uses listed
above, you may wonder if Ultravate is used for certain other conditions.
above, you may wonder if Ultravate is used for certain other conditions.
Ultravate for acne (not an
appropriate use)
appropriate use)
Ultravate shouldn’t be used to
treat acne, as the medication can make acne worse instead of better. If you
have acne that’s bothersome, ask your doctor what treatments are right for you.
treat acne, as the medication can make acne worse instead of better. If you
have acne that’s bothersome, ask your doctor what treatments are right for you.
Ultravate side effects
Ultravate can cause mild or
serious side effects. The following list contains some of the key side effects
that may occur while taking Ultravate. This list does not include all possible
side effects.
serious side effects. The following list contains some of the key side effects
that may occur while taking Ultravate. This list does not include all possible
side effects.
For more information on the
possible side effects of Ultravate, talk with your doctor or pharmacist. They
can give you tips on how to deal with any side effects that may be bothersome.
possible side effects of Ultravate, talk with your doctor or pharmacist. They
can give you tips on how to deal with any side effects that may be bothersome.
Note: The Food and Drug
Administration (FDA) tracks side effects of drugs it has approved. If you’d
like to report to the FDA a side effect you’ve had with Ultravate, you can do
so through MedWatch.
Administration (FDA) tracks side effects of drugs it has approved. If you’d
like to report to the FDA a side effect you’ve had with Ultravate, you can do
so through MedWatch.
More common side effects
The more common side effects
of Ultravate can include:
of Ultravate can include:
stinging, burning, or itching
of your skin
of your skin
- dry skin
- skin redness
- skin pustules
- skin atrophy (thinning)
- acne or bumps on the skin
- skin infection
- skin discoloration or
lightening - spider veins
- headache
If your skin condition gets
worse, or doesn’t go away within 2 weeks, talk with your doctor or pharmacist.
worse, or doesn’t go away within 2 weeks, talk with your doctor or pharmacist.
Serious side effects
Serious side effects from
Ultravate aren’t common, but they can occur. Call your doctor right away if you
have serious side effects. Call 911 if your symptoms feel life-threatening or
if you think you’re having a medical emergency.
Ultravate aren’t common, but they can occur. Call your doctor right away if you
have serious side effects. Call 911 if your symptoms feel life-threatening or
if you think you’re having a medical emergency.
Serious side effects,
explained in more detail below in “Side effect details,” include:
explained in more detail below in “Side effect details,” include:
- hypothalamic-pituitary-adrenal
axis suppression (a condition in which your adrenal glands shrink and don’t
work properly)
Side effect details
You may wonder how often
certain side effects occur with this drug. Here’s some detail on a few of the
side effects this drug may cause.
certain side effects occur with this drug. Here’s some detail on a few of the
side effects this drug may cause.
Hypothalamic-pituitary-adrenal
axis suppression
axis suppression
Hypothalamic-pituitary-adrenal
(HPA) axis suppression is a condition in which your adrenal glands shrink and
don’t work properly. HPA can occur when drugs called corticosteroids, such as
Ultravate, are applied to large areas of skin or are used in high doses for
long periods of time.
(HPA) axis suppression is a condition in which your adrenal glands shrink and
don’t work properly. HPA can occur when drugs called corticosteroids, such as
Ultravate, are applied to large areas of skin or are used in high doses for
long periods of time.
One sign of HPA axis
suppression is a condition called Cushing’s syndrome. Some signs of Cushing’s
syndrome include:
suppression is a condition called Cushing’s syndrome. Some signs of Cushing’s
syndrome include:
- weight gain in your face,
belly, and upper back - stretch marks
- thinning skin
- slow wound healing
- acne
- high blood sugar
HPA axis suppression is rare
and wasn’t seen in the Ultravate clinical studies.
and wasn’t seen in the Ultravate clinical studies.
If you use Ultravate for
longer than the recommended 2 weeks, your doctor may monitor you for HPA axis
suppression. If you do develop HPA axis suppression, your doctor may have you
stop taking Ultravate, reduce your dose, or switch you to a less strong
medication. Children and teenagers are more likely to develop HPA axis
suppression than adults.
longer than the recommended 2 weeks, your doctor may monitor you for HPA axis
suppression. If you do develop HPA axis suppression, your doctor may have you
stop taking Ultravate, reduce your dose, or switch you to a less strong
medication. Children and teenagers are more likely to develop HPA axis
suppression than adults.
Skin stinging, burning, or
itching
itching
Skin may sting, burn, or itch
where Ultravate is applied. In clinical studies of Ultravate cream, up to 4.4%
of people had these side effects. The cream wasn’t tested against a placebo
(treatment with no active drug).
where Ultravate is applied. In clinical studies of Ultravate cream, up to 4.4%
of people had these side effects. The cream wasn’t tested against a placebo
(treatment with no active drug).
If your skin condition gets
worse, tell your doctor. They may recommend a treatment other than Ultravate.
worse, tell your doctor. They may recommend a treatment other than Ultravate.
Skin thinning or atrophy
Skin atrophy (thinning) may
occur where Ultravate is applied. In clinical studies of Ultravate lotion, 1%
of people who used the medication had this side effect, compared with less than
1% of people who used a placebo lotion. Skin atrophy can appear as peeling,
red, or translucent skin.
occur where Ultravate is applied. In clinical studies of Ultravate lotion, 1%
of people who used the medication had this side effect, compared with less than
1% of people who used a placebo lotion. Skin atrophy can appear as peeling,
red, or translucent skin.
If your skin condition gets
worse, tell your doctor. They may recommend a treatment other than Ultravate.
worse, tell your doctor. They may recommend a treatment other than Ultravate.
Alternatives to Ultravate
Other drugs are available that
can treat your condition. Some may be better suited for you than others. If
you’re interested in finding an alternative to Ultravate, talk with your
doctor. They can tell you about other medications that may work well for you.
can treat your condition. Some may be better suited for you than others. If
you’re interested in finding an alternative to Ultravate, talk with your
doctor. They can tell you about other medications that may work well for you.
Note: Some of the drugs listed
here are used off-label to treat these specific conditions. Off-label drug use
is when a drug that’s approved for one use is used for a different one that’s
not approved.
here are used off-label to treat these specific conditions. Off-label drug use
is when a drug that’s approved for one use is used for a different one that’s
not approved.
Alternatives for plaque
psoriasis
psoriasis
Examples of other drugs that
may be used to treat plaque psoriasis include:
may be used to treat plaque psoriasis include:
- clobetasol propionate 0.05%
(Clobex, Olux, Clodan, Cormax, Temovate, Emeline) - betamethasone dipropionate
0.25% (Diprolene, Diprosone)
Alternatives for itching and
swelling from skin conditions that can be treated with a corticosteroid
swelling from skin conditions that can be treated with a corticosteroid
Examples of other drugs that
may be used for itching and swelling from skin conditions that can be treated
with a corticosteroid include:
may be used for itching and swelling from skin conditions that can be treated
with a corticosteroid include:
- clobetasol propionate 0.05%
(Clobex, Olux, Clodan, Cormax, Emeline) - betamethasone dipropionate
0.25% (Diprosone)
Ultravate vs. clobetasol
You may wonder how Ultravate
compares to other medications that are prescribed for similar uses. Here we
look at how Ultravate and clobetasol are alike and different.
compares to other medications that are prescribed for similar uses. Here we
look at how Ultravate and clobetasol are alike and different.
Ingredients
Ultravate contains the active
drug halobetasol. Clobetasol contains the active drug clobetasol.
drug halobetasol. Clobetasol contains the active drug clobetasol.
Uses
Both Ultravate and clobetasol
are strong corticosteroids used to treat plaque psoriasis. Corticosteroids are
a type of drug that reduces inflammation and eases swelling, redness, itching,
and other allergy symptoms.
are strong corticosteroids used to treat plaque psoriasis. Corticosteroids are
a type of drug that reduces inflammation and eases swelling, redness, itching,
and other allergy symptoms.
The two drugs are also
approved to treat skin itching and swelling due to skin conditions such as
eczema, poison ivy, and urticaria (hives).
approved to treat skin itching and swelling due to skin conditions such as
eczema, poison ivy, and urticaria (hives).
Drug forms and administration
Here’s some information about
the forms of each drug and how you take them.
the forms of each drug and how you take them.
Ultravate forms
Ultravate comes in three
different forms: lotion, cream, and ointment. Ultravate lotion is used to treat
plaque psoriasis in adults. Ultravate cream and ointment are used for skin
itching and swelling in adults as well as children ages 12 years and older.
different forms: lotion, cream, and ointment. Ultravate lotion is used to treat
plaque psoriasis in adults. Ultravate cream and ointment are used for skin
itching and swelling in adults as well as children ages 12 years and older.
You’ll apply Ultravate to the
affected parts of your skin once or twice a day for up to 2 weeks, or as your
doctor or pharmacist recommends. Because of risk of side effects, treatment
with Ultravate for longer than 2 weeks isn’t recommended. And you shouldn’t use
more than 50 g of Ultravate a week (50 mL a week of the lotion form). For more
about Ultravate side effects, see the “Side effects and risks” section below.
affected parts of your skin once or twice a day for up to 2 weeks, or as your
doctor or pharmacist recommends. Because of risk of side effects, treatment
with Ultravate for longer than 2 weeks isn’t recommended. And you shouldn’t use
more than 50 g of Ultravate a week (50 mL a week of the lotion form). For more
about Ultravate side effects, see the “Side effects and risks” section below.
Clobetasol forms
Clobetasol comes in several
different forms: topical gel, lotion, cream, spray, ointment, and foam. You’ll
apply clobetasol to the affected parts of your skin twice a day for up to 2
weeks, or as your doctor or pharmacist recommends.
different forms: topical gel, lotion, cream, spray, ointment, and foam. You’ll
apply clobetasol to the affected parts of your skin twice a day for up to 2
weeks, or as your doctor or pharmacist recommends.
Because of risk of side
effects, treatment with clobetasol for longer than 2 weeks isn’t recommended.
And you shouldn’t use more than 50 g of clobetasol a week (50 mL a week of the
lotion form). For more about side effects of clobetasol, see the “Side effects
and risks” section below.
effects, treatment with clobetasol for longer than 2 weeks isn’t recommended.
And you shouldn’t use more than 50 g of clobetasol a week (50 mL a week of the
lotion form). For more about side effects of clobetasol, see the “Side effects
and risks” section below.
Side effects and risks
Ultravate and clobetasol both
contain different topical corticosteroids. (“Topical” means that you apply them
to your skin.) Therefore, both medications can cause very similar side effects.
Below are examples of these side effects.
contain different topical corticosteroids. (“Topical” means that you apply them
to your skin.) Therefore, both medications can cause very similar side effects.
Below are examples of these side effects.
More common side effects
This list contains examples of
more common side effects that can occur with Ultravate, with clobetasol, or
with both drugs (when taken individually).
more common side effects that can occur with Ultravate, with clobetasol, or
with both drugs (when taken individually).
Can occur with Ultravate:
- few unique common side effects
Can occur with clobetasol:
- few unique common side effects
Can occur with both Ultravate
and clobetasol:
and clobetasol:
- stinging, burning, or itching
- dry skin
- skin redness
- skin pustules
- skin atrophy (thinning)
- acne or bumps on the skin
- skin infection
- skin discoloration or
lightening - spider veins
- headache
Serious side effects
This list contains examples of
serious side effects that can occur with Ultravate, with clobetasol, or with
both drugs (when taken individually).
serious side effects that can occur with Ultravate, with clobetasol, or with
both drugs (when taken individually).
Can occur with Ultravate:
- few unique serious side
effects
Can occur with clobetasol:
- few unique serious side
effects
Can occur with both Ultravate
and clobetasol
and clobetasol
- hypothalamic-pituitary-adrenal
axis suppression (a condition in which your adrenal glands shrink and don’t
work properly)
Effectiveness
Ultravate and clobetasol have
different FDA-approved uses, but they’re both used to treat plaque psoriasis
and skin itching and swelling associated with several dermatoses (skin
conditions). These skin conditions include eczema, poison ivy, and hives.
different FDA-approved uses, but they’re both used to treat plaque psoriasis
and skin itching and swelling associated with several dermatoses (skin
conditions). These skin conditions include eczema, poison ivy, and hives.
These drugs haven’t been
directly compared in clinical studies, but studies have found that Ultravate
lotion and clobetasol lotion are effective for treating plaque psoriasis.
directly compared in clinical studies, but studies have found that Ultravate
lotion and clobetasol lotion are effective for treating plaque psoriasis.
Studies have also found
Ultravate cream and ointment and clobetasol cream and ointment to be effective
for treating skin itching and swelling associated with several skin conditions.
These include eczema, poison ivy, and hives.
Ultravate cream and ointment and clobetasol cream and ointment to be effective
for treating skin itching and swelling associated with several skin conditions.
These include eczema, poison ivy, and hives.
Costs
Ultravate is a brand-name
drug, but it’s also available as a generic called halobetasol propionate 0.05%.
Clobetasol is a generic drug. Brand-name medications usually cost more than
generics.
drug, but it’s also available as a generic called halobetasol propionate 0.05%.
Clobetasol is a generic drug. Brand-name medications usually cost more than
generics.
According to estimates on
WellRx.com, brand-name and generic Ultravate lotion, cream, and ointment cost
significantly more than clobetasol lotion, cream, and ointment. The actual price
you’ll pay for either drug depends on your insurance plan, your location, and
the pharmacy you use.
WellRx.com, brand-name and generic Ultravate lotion, cream, and ointment cost
significantly more than clobetasol lotion, cream, and ointment. The actual price
you’ll pay for either drug depends on your insurance plan, your location, and
the pharmacy you use.
Ultravate vs. betamethasone
Like clobetasol (above), the
drug betamethasone has uses similar to those of Ultravate. Here’s a comparison
of how Ultravate and betamethasone are alike and different.
drug betamethasone has uses similar to those of Ultravate. Here’s a comparison
of how Ultravate and betamethasone are alike and different.
Ingredients
Ultravate contains the active
drug halobetasol. Betamethasone contains the active drug betamethasone.
drug halobetasol. Betamethasone contains the active drug betamethasone.
Uses
Both Ultravate and
betamethasone are strong corticosteroids used to treat plaque psoriasis.
Corticosteroids are a type of drug that reduces inflammation and eases
swelling, redness, itching, and other allergy symptoms.
betamethasone are strong corticosteroids used to treat plaque psoriasis.
Corticosteroids are a type of drug that reduces inflammation and eases
swelling, redness, itching, and other allergy symptoms.
The two drugs are also
approved to treat skin itching and swelling from several dermatoses (skin
conditions) such as eczema, poison ivy, and urticaria (hives).
approved to treat skin itching and swelling from several dermatoses (skin
conditions) such as eczema, poison ivy, and urticaria (hives).
Drug forms and administration
Here’s some information about
the forms of each drug and how you take them.
the forms of each drug and how you take them.
Ultravate forms
Ultravate comes in three
different forms: lotion, cream, and ointment. Ultravate lotion is used to treat
plaque psoriasis in adults. Ultravate cream and ointment are used for skin
itching and swelling in adults as well as children ages 12 years and older.
different forms: lotion, cream, and ointment. Ultravate lotion is used to treat
plaque psoriasis in adults. Ultravate cream and ointment are used for skin
itching and swelling in adults as well as children ages 12 years and older.
You’ll apply Ultravate to the
affected parts of your skin once or twice a day for up to 2 weeks, or as your
doctor or pharmacist recommends. Because of risk of side effects, treatment
with Ultravate for longer than 2 weeks isn’t recommended. And you shouldn’t use
more than 50 g of Ultravate a week (50 mL a week of the lotion form). For more
about Ultravate side effects, see the “Side effects and risks” section below.
affected parts of your skin once or twice a day for up to 2 weeks, or as your
doctor or pharmacist recommends. Because of risk of side effects, treatment
with Ultravate for longer than 2 weeks isn’t recommended. And you shouldn’t use
more than 50 g of Ultravate a week (50 mL a week of the lotion form). For more
about Ultravate side effects, see the “Side effects and risks” section below.
Betamethasone forms
Betamethasone comes in several
different forms: lotion, cream, ointment, gel, spray, and foam. You’ll apply
betamethasone to the affected parts of your skin once or twice a day for up to
2 weeks, or as your doctor or pharmacist recommends.
different forms: lotion, cream, ointment, gel, spray, and foam. You’ll apply
betamethasone to the affected parts of your skin once or twice a day for up to
2 weeks, or as your doctor or pharmacist recommends.
Because of risk of side
effects, treatment with betamethasone for longer than 2 weeks isn’t
recommended. And you shouldn’t use more than 50 g of betamethasone a week (50
mL a week of the lotion form). (For more about betamethasone side effects, see
the “Side effects and risks” section below.)
effects, treatment with betamethasone for longer than 2 weeks isn’t
recommended. And you shouldn’t use more than 50 g of betamethasone a week (50
mL a week of the lotion form). (For more about betamethasone side effects, see
the “Side effects and risks” section below.)
Side effects and risks
Ultravate and betamethasone
both contain strong corticosteroids. Therefore, both medications can cause very
similar side effects. Below are examples of these side effects.
both contain strong corticosteroids. Therefore, both medications can cause very
similar side effects. Below are examples of these side effects.
More common side effects
This list contains examples of
more common side effects that can occur with Ultravate, with betamethasone, or
with both drugs (when taken individually).
more common side effects that can occur with Ultravate, with betamethasone, or
with both drugs (when taken individually).
Can occur with Ultravate:
- few unique common side effects
Can occur with betamethasone:
- few unique common side effects
Can occur with both Ultravate
and betamethasone:
and betamethasone:
- stinging, burning, or itching
- dry skin
- skin redness
- skin pustules
- skin atrophy (thinning)
- acne or bumps on the skin
- skin infection
- skin discoloration or
lightening - spider veins
- headache
Serious side effects
This list contains examples of
serious side effects that can occur with Ultravate, with betamethasone, or with
both drugs (when taken individually).
serious side effects that can occur with Ultravate, with betamethasone, or with
both drugs (when taken individually).
Can occur with Ultravate:
- few unique serious side
effects
Can occur with betamethasone:
- few unique serious side
effects
Can occur with both Ultravate
and betamethasone
and betamethasone
- hypothalamic-pituitary-adrenal
axis suppression (a condition in which your adrenal glands shrink and don’t
work properly)
Effectiveness
Ultravate and betamethasone
have different FDA-approved uses. But they’re both used to treat plaque
psoriasis as well as skin itching and swelling from several dermatoses (skin
conditions). These skin conditions include eczema, poison ivy, and hives.
have different FDA-approved uses. But they’re both used to treat plaque
psoriasis as well as skin itching and swelling from several dermatoses (skin
conditions). These skin conditions include eczema, poison ivy, and hives.
These drugs haven’t been
directly compared in clinical studies, but studies have found that Ultravate
lotion and betamethasone ointment are effective for treating plaque psoriasis.
directly compared in clinical studies, but studies have found that Ultravate
lotion and betamethasone ointment are effective for treating plaque psoriasis.
Studies have also found Ultravate
cream and ointment and betamethasone cream, lotion, and ointment to be
effective for treating skin itching and swelling associated with several skin
conditions. These include eczema, poison ivy, and hives.
cream and ointment and betamethasone cream, lotion, and ointment to be
effective for treating skin itching and swelling associated with several skin
conditions. These include eczema, poison ivy, and hives.
Costs
Ultravate is a brand-name
drug, but it’s also available as a generic called halobetasol propionate 0.05%.
Betamethasone is a generic drug. Brand-name medications usually cost more than
generics.
drug, but it’s also available as a generic called halobetasol propionate 0.05%.
Betamethasone is a generic drug. Brand-name medications usually cost more than
generics.
According to estimates on
WellRx.com, brand-name and generic Ultravate lotion, cream, and ointment cost
significantly more than betamethasone lotion, cream, and ointment. The actual
price you’ll pay for either drug depends on your insurance plan, your location,
and the pharmacy you use.
WellRx.com, brand-name and generic Ultravate lotion, cream, and ointment cost
significantly more than betamethasone lotion, cream, and ointment. The actual
price you’ll pay for either drug depends on your insurance plan, your location,
and the pharmacy you use.
Ultravate dosage
The Ultravate dosage your
doctor prescribes will depend on several factors. These include:
doctor prescribes will depend on several factors. These include:
- the type and severity of the
condition you’re using Ultravate to treat - your age
- the form of Ultravate you use
- other medical conditions you
may have
The following information
describes dosages that are commonly used or recommended. However, be sure to
take the dosage your doctor prescribes for you. Your doctor will determine the
best dosage to suit your needs.
describes dosages that are commonly used or recommended. However, be sure to
take the dosage your doctor prescribes for you. Your doctor will determine the
best dosage to suit your needs.
Drug forms and strengths
Ultravate comes in several
different forms that are used to treat different conditions:
different forms that are used to treat different conditions:
- Ultravate lotion is used to
treat plaque psoriasis in adults. The medication comes in a bottle containing
60 mL (59 g) of 0.05% halobetasol propionate lotion. - Ultravate cream and ointment
are used to treat skin swelling or itching in adults as well as children ages
12 years and older. These forms of the drug come in tubes containing 50 g of
0.05% halobetasol propionate cream or ointment.
Dosage for plaque psoriasis
For plaque psoriasis, you’ll
apply Ultravate lotion as a thin layer to the affected areas of your skin and
rub it in gently. You’ll typically do this twice a day until you see an
improvement or for a maximum of 2 weeks.
apply Ultravate lotion as a thin layer to the affected areas of your skin and
rub it in gently. You’ll typically do this twice a day until you see an
improvement or for a maximum of 2 weeks.
Because of risk of side
effects, treatment with Ultravate lotion for longer than 2 weeks isn’t
recommended. And you shouldn’t use more than 50 g (50 mL) of Ultravate lotion a
week. (For more about Ultravate side effects, see the “Ultravate side effects”
section above.)
effects, treatment with Ultravate lotion for longer than 2 weeks isn’t
recommended. And you shouldn’t use more than 50 g (50 mL) of Ultravate lotion a
week. (For more about Ultravate side effects, see the “Ultravate side effects”
section above.)
If you don’t see an
improvement in your skin after 2 weeks, talk with your doctor. They may switch
you to a different medication.
improvement in your skin after 2 weeks, talk with your doctor. They may switch
you to a different medication.
You should use Ultravate
lotion only on your skin and never near your eyes or mouth. You shouldn’t use
the medication on your face, groin, or underarms unless your doctor tells you
to use it in these areas. Be sure to wash your hands after using Ultravate.
lotion only on your skin and never near your eyes or mouth. You shouldn’t use
the medication on your face, groin, or underarms unless your doctor tells you
to use it in these areas. Be sure to wash your hands after using Ultravate.
Dosage for skin conditions
that can be treated with a corticosteroid
that can be treated with a corticosteroid
Ultravate cream and ointment
are used to treat skin swelling and itching from conditions such as eczema,
poison ivy, and urticaria (hives). You’ll apply the medication as a thin layer
to the affected areas of your skin and rub it in gently. You’ll typically do
this once or twice a day until you see an improvement or for a maximum of 2
weeks.
Because of risk of side
effects, treatment with Ultravate cream or ointment for longer than 2 weeks
isn’t recommended. And you shouldn’t use more than 50 g of Ultravate cream or
ointment a week. (For more about Ultravate side effects, see the “Ultravate side
effects” section above.)
effects, treatment with Ultravate cream or ointment for longer than 2 weeks
isn’t recommended. And you shouldn’t use more than 50 g of Ultravate cream or
ointment a week. (For more about Ultravate side effects, see the “Ultravate side
effects” section above.)
If you don’t see an
improvement in your skin after 2 weeks, talk with your doctor. They may switch
you to a different medication.
improvement in your skin after 2 weeks, talk with your doctor. They may switch
you to a different medication.
You should use Ultravate cream
or ointment only on your skin and never near your eyes or mouth. You shouldn’t
use the medication on your face, groin, or underarms unless your doctor tells
you to use it in these areas. Be sure to wash your hands after using Ultravate.
or ointment only on your skin and never near your eyes or mouth. You shouldn’t
use the medication on your face, groin, or underarms unless your doctor tells
you to use it in these areas. Be sure to wash your hands after using Ultravate.
What if I miss a dose?
If you miss a dose of
Ultravate, try to use the drug as soon as you remember. Ultravate may not work
as well or may stop working if you miss a dose. For the medication to work
properly, you need to apply a certain amount to the affected areas of your skin
until they’re completely healed.
Ultravate, try to use the drug as soon as you remember. Ultravate may not work
as well or may stop working if you miss a dose. For the medication to work
properly, you need to apply a certain amount to the affected areas of your skin
until they’re completely healed.
Will I need to use this drug
long term?
long term?
Treatment with Ultravate for
longer than 2 weeks isn’t recommended because of the risk of side effects. If
you don’t see an improvement after 2 weeks, talk with your doctor. They may
switch you to a different medication.
longer than 2 weeks isn’t recommended because of the risk of side effects. If
you don’t see an improvement after 2 weeks, talk with your doctor. They may
switch you to a different medication.
Ultravate and alcohol
There are no known
interactions between alcohol and Ultravate.
interactions between alcohol and Ultravate.
If you drink alcohol and are
concerned about how it might interact with Ultravate, talk with your doctor.
They can tell you how much is safe for you to drink during your treatment.
concerned about how it might interact with Ultravate, talk with your doctor.
They can tell you how much is safe for you to drink during your treatment.
Ultravate interactions
There are no known drug
interactions between Ultravate and other medications.
interactions between Ultravate and other medications.
Ultravate and herbs and
supplements
supplements
There aren’t any herbs or
supplements that have been specifically reported to interact with Ultravate.
However, you should still check with your doctor or pharmacist before using any
of these products while taking Ultravate.
supplements that have been specifically reported to interact with Ultravate.
However, you should still check with your doctor or pharmacist before using any
of these products while taking Ultravate.
Ultravate and foods
There are no known
interactions between Ultravate and any foods.
interactions between Ultravate and any foods.
Ultravate cost
As with all medications, the
cost of Ultravate can vary. To find current prices for Ultravate in your area,
check out WellRx.com. The cost you find on WellRx.com is what you may pay
without insurance. The actual price you’ll pay depends on your insurance plan,
your location, and the pharmacy you use.
cost of Ultravate can vary. To find current prices for Ultravate in your area,
check out WellRx.com. The cost you find on WellRx.com is what you may pay
without insurance. The actual price you’ll pay depends on your insurance plan,
your location, and the pharmacy you use.
Your insurance company may
require you to get prior authorization before they approve coverage for
Ultravate. This means that your doctor will need to send a request to your
insurance company asking them to cover the drug. The insurance company will review
the request and let you and your doctor know if your plan will cover Ultravate.
require you to get prior authorization before they approve coverage for
Ultravate. This means that your doctor will need to send a request to your
insurance company asking them to cover the drug. The insurance company will review
the request and let you and your doctor know if your plan will cover Ultravate.
If you’re not sure if you’ll
need to get prior authorization for Ultravate, contact your insurance company.
need to get prior authorization for Ultravate, contact your insurance company.
Financial assistance
If you need financial support
to pay for Ultravate, help is available. Sun Pharmaceutical Industries, Inc.,
the manufacturer of Ultravate, offers the TaroPharma Copay Program. For more
information and to find out if you’re eligible for support, visit the program
website.
to pay for Ultravate, help is available. Sun Pharmaceutical Industries, Inc.,
the manufacturer of Ultravate, offers the TaroPharma Copay Program. For more
information and to find out if you’re eligible for support, visit the program
website.
How to use Ultravate
You should use Ultravate
according to your doctor’s or healthcare provider’s instructions.
according to your doctor’s or healthcare provider’s instructions.
You’ll apply Ultravate as a
thin layer to the affected areas of your skin and rub it in gently. You’ll
typically do this once or twice a day until you see an improvement or for a
maximum of 2 weeks.
thin layer to the affected areas of your skin and rub it in gently. You’ll
typically do this once or twice a day until you see an improvement or for a
maximum of 2 weeks.
Because of risk of side
effects, treatment with Ultravate for longer than 2 weeks isn’t recommended.
And you shouldn’t use more than 50 g of Ultravate a week. (For more about
Ultravate side effects, see the “Ultravate side effects” section above.)
effects, treatment with Ultravate for longer than 2 weeks isn’t recommended.
And you shouldn’t use more than 50 g of Ultravate a week. (For more about
Ultravate side effects, see the “Ultravate side effects” section above.)
If you don’t see an
improvement in your skin after 2 weeks, talk with your doctor. They may switch
you to a different medication.
improvement in your skin after 2 weeks, talk with your doctor. They may switch
you to a different medication.
You should use Ultravate only
on your skin and never near your eyes or mouth. You shouldn’t use the
medication on your face, groin, or underarms unless your doctor tells you to
use it in these areas. Be sure to wash your hands after using Ultravate.
on your skin and never near your eyes or mouth. You shouldn’t use the
medication on your face, groin, or underarms unless your doctor tells you to
use it in these areas. Be sure to wash your hands after using Ultravate.
When to take
You’ll typically apply
Ultravate to your skin once or twice a day until you see an improvement or for
a maximum of 2 weeks.
Ultravate to your skin once or twice a day until you see an improvement or for
a maximum of 2 weeks.
How Ultravate works
Ultravate is available in
three forms: lotion, cream, and ointment.
three forms: lotion, cream, and ointment.
Ultravate lotion for plaque
psoriasis
psoriasis
Ultravate lotion is used to
treat plaque psoriasis, which is the most common form of psoriasis. Plaque
psoriasis occurs when your immune system is overactive, and your body makes
skin cells too rapidly. (Your immune system is your body’s defense against
infection.) This causes excess skin cells to build up on your skin’s surface.
The buildup typically appears as raised, red patches that may be covered with
silver or white scales. These patches are known as “plaques.”
treat plaque psoriasis, which is the most common form of psoriasis. Plaque
psoriasis occurs when your immune system is overactive, and your body makes
skin cells too rapidly. (Your immune system is your body’s defense against
infection.) This causes excess skin cells to build up on your skin’s surface.
The buildup typically appears as raised, red patches that may be covered with
silver or white scales. These patches are known as “plaques.”
Ultravate cream and ointment
for various skin conditions
for various skin conditions
Ultravate cream and ointment
are used for skin inflammation (swelling) and itching from skin conditions that
can be treated with a drug called a corticosteroid. Ultravate itself is a
corticosteroid. Some of the skin conditions that the cream and ointment may be
used for include eczema, poison ivy, and urticaria (hives).
Eczema is a condition that
makes your skin itchy and red, although symptoms can vary from person to
person. Eczema occurs when your skin can’t protect itself and retain moisture.
makes your skin itchy and red, although symptoms can vary from person to
person. Eczema occurs when your skin can’t protect itself and retain moisture.
Poison ivy rash results from
your skin coming in contact with a substance called urushiol. This is a sap
that’s found on the stems, leaves, and roots of the poison ivy plant. Symptoms
of poison ivy rash include skin that’s itchy, red, or swollen, and blisters
that may leak.
your skin coming in contact with a substance called urushiol. This is a sap
that’s found on the stems, leaves, and roots of the poison ivy plant. Symptoms
of poison ivy rash include skin that’s itchy, red, or swollen, and blisters
that may leak.
Hives, which are also called
urticaria, are a type of rash that causes your skin to be itchy, red, and have
spots of swelling. These spots (welts) can be large or small.
urticaria, are a type of rash that causes your skin to be itchy, red, and have
spots of swelling. These spots (welts) can be large or small.
Hives result from a release of
a chemical called histamine into your bloodstream. Your immune system (your
body’s defense against infection) responds to histamine by causing redness and
itching.
a chemical called histamine into your bloodstream. Your immune system (your
body’s defense against infection) responds to histamine by causing redness and
itching.
Hives can be triggered by
infections, changes in temperature, stress, sunlight, or certain foods.
infections, changes in temperature, stress, sunlight, or certain foods.
What Ultravate does
Because it’s not clear what
causes plaque psoriasis, how Ultravate works to treat the condition isn’t
completely understood. Ultravate does block the overreactive immune response
from your cells that causes redness and inflammation (swelling). This helps
control the skin conditions mentioned above, as well as inflammation and
itching due to general skin irritation, such as plaque psoriasis.
causes plaque psoriasis, how Ultravate works to treat the condition isn’t
completely understood. Ultravate does block the overreactive immune response
from your cells that causes redness and inflammation (swelling). This helps
control the skin conditions mentioned above, as well as inflammation and
itching due to general skin irritation, such as plaque psoriasis.
How long does it take to work?
Most people begin to see their
symptoms improve within a few days of using Ultravate. The maximum effect is
typically seen after about 4 days.
symptoms improve within a few days of using Ultravate. The maximum effect is
typically seen after about 4 days.
Your skin starts to absorb
Ultravate once you apply it to the affected areas. But each person will respond
to the medication differently, and symptoms may ease faster in some people than
in others.
Ultravate once you apply it to the affected areas. But each person will respond
to the medication differently, and symptoms may ease faster in some people than
in others.
Ask your doctor or pharmacist
how long you should use Ultravate. Typically, treatment with Ultravate for
longer than 2 weeks isn’t recommended because of the risk of side effects. And
you shouldn’t use more than 50 g of Ultravate a week (50 mL a week of the
lotion form).
how long you should use Ultravate. Typically, treatment with Ultravate for
longer than 2 weeks isn’t recommended because of the risk of side effects. And
you shouldn’t use more than 50 g of Ultravate a week (50 mL a week of the
lotion form).
Ultravate and pregnancy
Ultravate should be used in
pregnancy only if the benefit to the mother outweighs any possible harm to the
baby.
pregnancy only if the benefit to the mother outweighs any possible harm to the
baby.
Research in animals has shown
birth defects in babies when the pregnant mothers were given Ultravate.
However, animal studies don’t always predict what will happen in humans. And
there haven’t been enough studies done in pregnant women to be certain how
Ultravate might affect the baby.
birth defects in babies when the pregnant mothers were given Ultravate.
However, animal studies don’t always predict what will happen in humans. And
there haven’t been enough studies done in pregnant women to be certain how
Ultravate might affect the baby.
If you’re pregnant or planning
on becoming pregnant, talk with your doctor. They can help you review the pros
and cons of using Ultravate and suggest a different medication, if needed.
on becoming pregnant, talk with your doctor. They can help you review the pros
and cons of using Ultravate and suggest a different medication, if needed.
Ultravate and birth control
It’s not known if Ultravate is
safe to take during pregnancy. If you’re sexually active and you or your
partner can become pregnant, talk with your doctor about your birth control
needs while you’re using Ultravate.
safe to take during pregnancy. If you’re sexually active and you or your
partner can become pregnant, talk with your doctor about your birth control
needs while you’re using Ultravate.
Ultravate and breastfeeding
It’s not known if Ultravate is
safe to use while you’re breastfeeding. The drug may pass into breast milk and
cause side effects such as slower growth. Ultravate may also affect how well breastfed
children make corticosteroids, which are a type of hormone that helps control
inflammation (swelling).
safe to use while you’re breastfeeding. The drug may pass into breast milk and
cause side effects such as slower growth. Ultravate may also affect how well breastfed
children make corticosteroids, which are a type of hormone that helps control
inflammation (swelling).
If you’re using Ultravate and
want to breastfeed your child, talk with your doctor. They can help you decide
on the best way to feed your child and suggest a treatment other than
Ultravate, if needed.
want to breastfeed your child, talk with your doctor. They can help you decide
on the best way to feed your child and suggest a treatment other than
Ultravate, if needed.
Common questions about
Ultravate
Ultravate
Here are answers to some
frequently asked questions about Ultravate.
frequently asked questions about Ultravate.
Can I use Ultravate on my
face?
face?
You shouldn’t use Ultravate on
your face unless your doctor tells you to use it there. And be sure to never
put the medication near your eyes or mouth. This is because of the risk of side
effects such as skin thinning, acne, and irritation on the face.
your face unless your doctor tells you to use it there. And be sure to never
put the medication near your eyes or mouth. This is because of the risk of side
effects such as skin thinning, acne, and irritation on the face.
There have also been reports of
rare eye-related side effects when corticosteroid creams such as Ultravate were
used for a long time on the face or around the eyes. These side effects
included an increase in eye pressure, vision loss, and cataracts.
rare eye-related side effects when corticosteroid creams such as Ultravate were
used for a long time on the face or around the eyes. These side effects
included an increase in eye pressure, vision loss, and cataracts.
Is Ultravate a steroid?
Yes. Ultravate contains the
ingredient halobetasol propionate, which is a type of drug called a topical
corticosteroid. (“Topical” means that you apply it to your skin.)
Corticosteroids are often called steroids.
ingredient halobetasol propionate, which is a type of drug called a topical
corticosteroid. (“Topical” means that you apply it to your skin.)
Corticosteroids are often called steroids.
The skin conditions that
Ultravate is used to treat are due to inflammation (swelling) and an overactive
immune system. (Your immune system is your body’s defense against infection.)
Corticosteroids help ease inflammation and reduce how active your immune system
is. The drugs do this by interacting with proteins in your body that produce a
histamine response. (Histamine is a chemical in your body that drives allergic
responses such as redness and swelling.) This helps reduce skin itching and
irritation.
Ultravate is used to treat are due to inflammation (swelling) and an overactive
immune system. (Your immune system is your body’s defense against infection.)
Corticosteroids help ease inflammation and reduce how active your immune system
is. The drugs do this by interacting with proteins in your body that produce a
histamine response. (Histamine is a chemical in your body that drives allergic
responses such as redness and swelling.) This helps reduce skin itching and
irritation.
Will it cure my plaque
psoriasis?
psoriasis?
No, there isn’t currently a
cure for plaque psoriasis. The goal of Ultravate is to help clear up plaques,
which are the raised, red patches on skin that may be covered with silver or
white scales.
cure for plaque psoriasis. The goal of Ultravate is to help clear up plaques,
which are the raised, red patches on skin that may be covered with silver or
white scales.
If you have questions about
Ultravate or other treatments for plaque psoriasis, ask your doctor.
Ultravate or other treatments for plaque psoriasis, ask your doctor.
Can I place bandages over
Ultravate on my skin?
Ultravate on my skin?
You shouldn’t put bandages or
dressings over Ultravate unless your doctor or pharmacist specifically directs
you to. Placing a bandage or dressing over the medication can cause your skin and
body to absorb too much Ultravate. This can increase your risk for side effects
and skin irritation. For more about possible side effects, see the “Ultravate
side effects” section above.
dressings over Ultravate unless your doctor or pharmacist specifically directs
you to. Placing a bandage or dressing over the medication can cause your skin and
body to absorb too much Ultravate. This can increase your risk for side effects
and skin irritation. For more about possible side effects, see the “Ultravate
side effects” section above.
If you’re concerned about not
bandaging your skin during Ultravate treatment, talk with your doctor.
bandaging your skin during Ultravate treatment, talk with your doctor.
Ultravate precautions
Before taking Ultravate, talk
with your doctor about your health history. Ultravate may not be right for you
if you have certain medical conditions or other factors affecting your health.
These include:
with your doctor about your health history. Ultravate may not be right for you
if you have certain medical conditions or other factors affecting your health.
These include:
- Allergic reactions. If you
have an allergy to Ultravate or its ingredients, you shouldn’t take the
medication. Talk with your doctor about other possible treatments. - Skin infections. If you have a
skin infection, your doctor will likely treat it while you use Ultravate. But
if the infection doesn’t clear up, they may want you to stop using Ultravate
until the skin infection goes away. - Hypothalamic-pituitary-adrenal
axis suppression or Cushing’s syndrome. Applying corticosteroids, such as
Ultravate, to large areas of your body or using high doses for long periods of
time may cause certain hormone conditions. These include
hypothalamic-pituitary-adrenal (HPA) axis suppression and Cushing’s syndrome.
(For symptoms, see the “Ultravate side effects” section above.) If you have a
history of either of these conditions, tell your doctor before you start taking
Ultravate. Your doctor may recommend a different treatment or recommend that
you use Ultravate for a shorter time. - Type 1 or type 2 diabetes. If
you have type 1 or type 2 diabetes, it’s important that you use topical
steroids, such as Ultravate, carefully. (“Topical” means that you apply it to
your skin.) Steroids have been known to increase blood sugar if used for long
periods, as well as delay the healing of skin ulcers (open wounds). Before you
start using Ultravate, tell your doctor if you have type 1 or type 2 diabetes.
Your doctor may recommend a different treatment or recommend that you use
Ultravate for a shorter time. - Pregnancy. Ultravate should be
used in pregnancy only if the benefit to the mother outweighs any possible harm
to the baby. For more information, please see the “Ultravate and pregnancy”
section above. - Breastfeeding. It’s not known
if Ultravate is safe to use while you’re breastfeeding. For more information,
please see the “Ultravate and breastfeeding” section above.
Note: For more information
about the potential negative effects of Ultravate, see the “Ultravate side
effects” section above.
about the potential negative effects of Ultravate, see the “Ultravate side
effects” section above.
Ultravate overdose
An Ultravate overdose is rare,
but it can occur if you:
but it can occur if you:
- apply too much Ultravate to a
large area of skin for longer than 2 weeks - put a bandage or dressing over
Ultravate on your skin - use Ultravate for longer than
2 weeks or for longer than your doctor tells you to
Overdose symptoms
Symptoms of an overdose can
include hypothalamic-pituitary-adrenal (HPA) axis suppression. This is a
condition in which your adrenal glands shrink and don’t work properly. One sign
of HPA axis suppression is a condition called Cushing’s syndrome. Some symptoms
of Cushing’s syndrome include:
include hypothalamic-pituitary-adrenal (HPA) axis suppression. This is a
condition in which your adrenal glands shrink and don’t work properly. One sign
of HPA axis suppression is a condition called Cushing’s syndrome. Some symptoms
of Cushing’s syndrome include:
- weight gain in your face,
belly, and upper back - stretch marks
- thinning skin
- slow wound healing
- acne
- high blood sugar
HPA axis suppression is rare
and wasn’t seen in the Ultravate clinical studies.
and wasn’t seen in the Ultravate clinical studies.
What to do in case of overdose
If you think you’ve taken too
much of this drug, call your doctor. You can also call the American Association
of Poison Control Centers at 800-222-1222 or use their online tool. But if your
symptoms are severe, call 911 or go to the nearest emergency room right away.
much of this drug, call your doctor. You can also call the American Association
of Poison Control Centers at 800-222-1222 or use their online tool. But if your
symptoms are severe, call 911 or go to the nearest emergency room right away.
Ultravate expiration, storage,
and disposal
and disposal
When you get Ultravate from
the pharmacy, the pharmacist will add an expiration date to the label on the
bottle or tube. This date is typically 1 year from the date they dispensed the
medication.
the pharmacy, the pharmacist will add an expiration date to the label on the
bottle or tube. This date is typically 1 year from the date they dispensed the
medication.
The expiration date helps
guarantee the effectiveness of the medication during this time. The current
stance of the Food and Drug Administration (FDA) is to avoid using expired
medications. If you have unused medication that has gone past the expiration
date, talk with your pharmacist about whether you might still be able to use
it.
guarantee the effectiveness of the medication during this time. The current
stance of the Food and Drug Administration (FDA) is to avoid using expired
medications. If you have unused medication that has gone past the expiration
date, talk with your pharmacist about whether you might still be able to use
it.
Storage
How long a medication remains
good can depend on many factors, including how and where you store the
medication.
good can depend on many factors, including how and where you store the
medication.
You should store Ultravate
lotion at room temperature (around 77°F/25°C) and keep it in the bottle the
pharmacist dispensed it in.
lotion at room temperature (around 77°F/25°C) and keep it in the bottle the
pharmacist dispensed it in.
You should store Ultravate
cream and ointment at room temperature between 59°F and 86°F (15°C and 30°C).
Keep them in the tube the pharmacist dispensed them in.
cream and ointment at room temperature between 59°F and 86°F (15°C and 30°C).
Keep them in the tube the pharmacist dispensed them in.
Disposal
If you no longer need to take
Ultravate and have leftover medication, it’s important to dispose of it safely.
This helps prevent others, including children and pets, from taking the drug by
accident. It also helps keep the drug from harming the environment.
Ultravate and have leftover medication, it’s important to dispose of it safely.
This helps prevent others, including children and pets, from taking the drug by
accident. It also helps keep the drug from harming the environment.
You can find useful tips on
medication disposal here. You can also ask your pharmacist for tips on how to
dispose of your medication.
medication disposal here. You can also ask your pharmacist for tips on how to
dispose of your medication.
Professional information for
Ultravate
Ultravate
The following information is
provided for clinicians and other healthcare professionals.
provided for clinicians and other healthcare professionals.
Indications
Ultravate is indicated to
treat plaque psoriasis and inflammation and itching associated with skin
dermatoses that actively respond to corticosteroids.
treat plaque psoriasis and inflammation and itching associated with skin
dermatoses that actively respond to corticosteroids.
Mechanism of action
Ultravate contains the
super-potent topical corticosteroid halobetasol propionate, whose exact
mechanism of action is unknown. Corticosteroids are believed to act as
antipruritic and vasoconstrictive agents through induction of inhibition of the
release of arachidonic acid, a precursor for prostaglandins and leukotrienes,
both inflammation mediators.
super-potent topical corticosteroid halobetasol propionate, whose exact
mechanism of action is unknown. Corticosteroids are believed to act as
antipruritic and vasoconstrictive agents through induction of inhibition of the
release of arachidonic acid, a precursor for prostaglandins and leukotrienes,
both inflammation mediators.
Pharmacokinetics and
metabolism
metabolism
Absorption of Ultravate is
variable and dependent upon the vehicle or formulation, skin integrity, and
presence or absence of occlusive dressings. Human studies suggest approximately
6% of the applied dose enters the circulation at a mean of 96 hours after
initial application. One study of 12 adult subjects receiving halobetasol
propionate topically for 8 days showed maximum plasma concentrations 3 hours
after application.
variable and dependent upon the vehicle or formulation, skin integrity, and
presence or absence of occlusive dressings. Human studies suggest approximately
6% of the applied dose enters the circulation at a mean of 96 hours after
initial application. One study of 12 adult subjects receiving halobetasol
propionate topically for 8 days showed maximum plasma concentrations 3 hours
after application.
Ultravate is metabolized in
the liver, and excretion occurs through the urine and bile.
the liver, and excretion occurs through the urine and bile.
Contraindications
Ultravate is contraindicated
in patients who have a history of hypersensitivity to Ultravate or any of its
components.
in patients who have a history of hypersensitivity to Ultravate or any of its
components.
Storage
Ultravate lotion should be
kept at room temperature around 77°F (25°C). However, excursions are allowed
between 59°F and 86°F (15°C and 30°C). Don’t freeze the lotion.
kept at room temperature around 77°F (25°C). However, excursions are allowed
between 59°F and 86°F (15°C and 30°C). Don’t freeze the lotion.
Ultravate cream and ointment
should be kept at room temperature between 59°F and 86°F (15°C and 30°C).
should be kept at room temperature between 59°F and 86°F (15°C and 30°C).
Disclaimer: Medical News Today
has made every effort to make certain that all information is factually
correct, comprehensive, and up-to-date. However, this article should not be
used as a substitute for the knowledge and expertise of a licensed healthcare
professional. You should always consult your doctor or other healthcare
professional before taking any medication. The drug information contained
herein is subject to change and is not intended to cover all possible uses,
directions, precautions, warnings, drug interactions, allergic reactions, or
adverse effects. The absence of warnings or other information for a given drug
does not indicate that the drug or drug combination is safe, effective, or
appropriate for all patients or all specific uses.
has made every effort to make certain that all information is factually
correct, comprehensive, and up-to-date. However, this article should not be
used as a substitute for the knowledge and expertise of a licensed healthcare
professional. You should always consult your doctor or other healthcare
professional before taking any medication. The drug information contained
herein is subject to change and is not intended to cover all possible uses,
directions, precautions, warnings, drug interactions, allergic reactions, or
adverse effects. The absence of warnings or other information for a given drug
does not indicate that the drug or drug combination is safe, effective, or
appropriate for all patients or all specific uses.
Medically reviewed by Victor
Nguyen, PharmD, MBA
Nguyen, PharmD, MBA
Written by Yelena Davydovskaya,
PharmD
PharmD
SOURCE:
MEDICAL NEWS TODAY
MEDICAL NEWS TODAY
Kayode Emmanuel Ojo is the Co-Founder and Managing Director at SHEFFA Limited. He is presently studying Computer Science at the National Open University, Victoria Island, Lagos.